Comprehensive Perioperative Program Based on Prehabilitation, Nutritional Intervention and Psychological Support for Patients With Locally Advanced Operable Oesophagogastric Cancer

Summary

Perioperative chemotherapy (CHT) or CHT/RT combined with surgery is the standard therapeutic approach for the treatment of locally advanced cancer of the esophagus, gastroesophageal junction (GEJ), and stomach. Comprehensive cancer treatment is associated with high perioperative morbidity and mortality. Serious postoperative complications occur in up to 20-80% of patients undergoing esophagectomy. The impact of nutritional status and overall physical condition on surgical outcomes and overall treatment has been demonstrated many times. The concept of pre-rehabilitation/pre-optimization, which involves establishing an individualized nutritional plan, monitoring and managing physical activity, and providing comprehensive supportive oncological and psychological care as early as during neoadjuvant CHT or CHT/RT, is a prerequisite for improving perioperative and 30-day postoperative morbidity and mortality.

Eligibility

Inclusion Criteria:

* Consent to participate in the study
* Age ≥ 18 years
* Patients with locally advanced esophageal or gastric cancer indicated for comprehensive perioperative treatment
* Resectable disease
* ECOG performance status 0-2
* Ability to participate in a fitness program
* Willingness to follow a nutritional plan and recommendations

Exclusion Criteria:

* Disseminated disease

Conditions4

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