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Etiologic Diagnosis Algorithm in Infective Endocarditis

RECRUITINGN/ASponsored by I.M. Sechenov First Moscow State Medical University
Actively Recruiting
PhaseN/A
SponsorI.M. Sechenov First Moscow State Medical University
Started2026-01-20
Est. completion2027-02-04
Eligibility
Age18 Years+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07682389

Summary

The goal of this study is to evaluate the impact of a diagnostic algorithm combining culture-based and molecular methods on the frequency of etiotropic antibiotic therapy prescription within 14 days of diagnosis of infective endocarditis

Eligibility

Age: 18 Years+Healthy volunteers accepted
Inclusion Criteria:

* Informed consent,
* Age ≥ 18,
* IE (definite or possible per the 2023 Duke-International Society for Cardiovascular Infectious Diseases Criteria for Infective Endocarditis)

Exclusion Criteria:

* Pregnancy/breastfeeding
* Unconfirmed or rejected IE diagnosis,
* Very high risk of death within 14 days due to severe complications of the main or concomitant disease(s), according to the physician's opinion;
* Prior use of antibiotic therapy (except documented treatment failure).

Conditions3

Heart DiseaseInfective EndocarditisMicrobiology

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