Noninvasive Artificial Venous Stasis for Reperfusion in STEMI

Summary

This prospective, randomized study was designed to evaluate whether the noninvasive artificial venous stasis / RE-START procedure, administered prior to primary percutaneous coronary intervention, increases the frequency of spontaneous coronary reperfusion in the infarct-related artery.

Eligibility

Inclusion Criteria:

* Having presented within the first 12 hours of symptom onset Being hemodynamically stable (Killip Class I-II)

  * STEMI diagnosis confirmed by coronary angiography
  * Primary PCI (percutaneous coronary intervention) scheduled
  * No pathology in the upper extremity that would prevent cuff application
  * Be capable of providing informed consent and provide consent

Exclusion Criteria:

* Presence of cardiogenic shock (systolic blood pressure \< 90 mmHg and Killip Class III-IV)

  * Cardiac arrest occurring before or after the procedure
  * Need for resuscitation following failed thrombolysis
  * History of prior coronary artery bypass surgery
  * Concurrent acute aortic dissection
  * Venous thromboembolism or pulmonary embolism
  * History of an acute infection within the past 7 days
  * Chronic kidney disease requiring erythropoietin therapy or currently undergoing hemodialysis
  * Presence of liver failure or a hematologic disorder
  * Presence of any chronic inflammatory or autoimmune disease
  * History of any known malignancy (cancer)
  * Current treatment with glibenclamide, corticosteroids, antioxidant vitamins, or cyclosporine at the time of enrollment
  * History of chronic (daily) alcohol consumption
  * Contraindications to aspirin and/or clopidogrel
  * Failure to confirm a STEMI diagnosis via coronary angiography
  * Inability to provide informed consent
  * Pregnancy
  * First 6 months postpartum Conditions in which the administration of thrombolytics is contraindicated

Conditions2

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