HLA B Leader in Patients With Psoriatic Arthritis

Summary

Psoriatic arthritis (PsA), a chronic immune-mediated heterogeneous inflammatory disease characterized by musculoskeletal inflammation (arthritis, enthesitis, spondylitis and dactylitis), usually occurs in patients with psoriasis. The spondyloarthritides (SPs) (of which psoriasis is one) are a group of inflammatory diseases that share an association with the HLA-B27 MHC class I molecule. Given this association, these diseases are classically regarded as disorders of adaptive immunity. In bone marrow donation, HLA-B exon 1 dimorphism (HLAB leader) is associated with risk of graft- versus-host disease, relapse and overall survival after unrelated hematopoietic cell transplantation (UHCT), haploidentical UHCT and cord transplantation. In the literature, there are no studies suggesting the involvement of the HLA B leader gene in MS and RPs. The main aim of this study is to compare the presence of the HLA B leader gene between a group of patients with psoriatic arthritis and a healthy group without inflammatory disease.

Eligibility

Inclusion Criteria:

* For the "Patient" group:
* Patient over 18 years of age
* Patient affiliated to a social security scheme
* Patient with psoriatic arthritis according to the CASPAR 2006 classification, followed at the CHU Amiens-Picardie.
* For the "control" group:
* Individuals over 18 years of age
* Individual affiliated to a social security scheme
* Individual having agreed to participate in the study
* Individuals with no inflammatory or autoimmune diseases

Exclusion Criteria:

* Patient or control not understanding French
* Patient not included in the Amiens Picardie University Hospital's "Psoriatic Rheumatism" cohort, or control not included in the Amiens Picardie University Hospital's bone marrow donor cohort.
* Patient or control objecting to participation in the study

Conditions4

Interventions1

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