Eccentric vs Low-Load Blood Flow Restriction Training in Knee Osteoarthritis in Knee Osteoarthritis

Summary

The aim of this randomized controlled trial is to find the effects of eccentric and low-load blood flow restriction training on neuromuscular adaptations, muscle strength, functional performance, and disability in patients with knee osteoarthritis

Eligibility

Inclusion Criteria:

* Age group 40-70
* Both genders male and female
* Clinical diagnosis of knee OA (Kellgren-Lawrence grade 1-3) of the most symptomatic knee.
* Pain stable enough to permit exercise on Numeric Pain Rating Scale 3/10.
* Participants must demonstrate a gastrocnemius muscle strength of grade ≥3 on the Manual Muscle Testing (MMT) scale (0-5), assessed using the standard standing heel-rise position.
* Participants must be able to ambulate independently and participate in supervised exercise.

Exclusion Criteria:

* • Presence of a prosthetic knee in the affected limb.

  * Inflammatory arthritis (e.g., rheumatoid arthritis) or active flare-up of OA.
  * Cardiovascular disease contraindicating exercise (e.g., unstable angina, recent MI, uncontrolled hypertension ≥160/100 mmHg).
  * Pulmonary disease that limits safe participation (e.g., severe COPD, recent exacerbation).
  * History of deep vein thrombosis (DVT), peripheral vascular disease, or bleeding/clotting disorders.
  * Current anticoagulant therapy that increases bleeding risk (unless cleared by physician).
  * Any pathology causing significant muscle weakness (e.g., neuromuscular disorders, severe neuropathy).

Conditions2

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