Peripheral Blood Lipidomic and Ceramide Profiles in Atrial Fibrillation

Summary

This prospective multi-cohort observational study evaluates the association between peripheral blood lipidomic and ceramide profiles and atrial fibrillation. The study hypothesis is that peripheral blood lipidomic features and ceramide-related profiles are associated with the presence of atrial fibrillation. Participants with atrial fibrillation and control participants with other cardiovascular diseases will be prospectively enrolled. Peripheral blood samples will be analyzed using untargeted lipidomic profiling in one cohort and targeted ceramide assays in another cohort.

Eligibility

Inclusion Criteria:

* Adults aged 18 years or older.
* Participants who are able to provide informed consent.
* Participants diagnosed with atrial fibrillation based on Holter monitoring, or control participants with other cardiovascular diseases and no documented atrial fibrillation.
* Participants with available peripheral blood samples for untargeted lipidomic profiling or targeted ceramide analysis.

Exclusion Criteria:

* Inability or unwillingness to provide informed consent.
* Missing key clinical information.
* Missing or poor-quality peripheral blood samples unsuitable for lipidomic or targeted ceramide analysis.
* Participants considered unsuitable for this study by the investigators.

Conditions2

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