Photon-Counting Cardiac CT in Post-PCI Patients

Summary

This study takes patients who have undergone percutaneous coronary intervention as the research subjects and employs a prospective observational cohort design, aiming to develop and validate a "one-stop" photon-counting computed tomography imaging framework. The one-stop PCCT protocol implies that multiple assessments are acquired through a single examination, including coronary CT angiography for stent and native artery evaluation, resting first-pass myocardial iodine distribution imaging, and delayed myocardial extracellular volume quantification, with cardiac cine imaging performed in a prespecified dose-controlled substudy.

Eligibility

Inclusion Criteria:

1. Age 18 years or older;
2. History of percutaneous coronary intervention with implantation of at least one coronary stent;
3. Ability to undergo iodinated contrast-enhanced CT;
4. Ability and willingness to provide written informed consent.

Exclusion Criteria:

1. Estimated glomerular filtration rate below the institutional threshold for contrast-enhanced CT, generally less than 30 mL/min/1.73 m², unless examination is clinically justified and approved according to institutional policy;
2. Known severe hypersensitivity to iodinated contrast material that cannot be adequately managed using the institutional premedication protocol; Pregnancy or suspected pregnancy;
3. Inability to provide informed consent or comply with study procedures;
4. Severe respiratory inability to perform the required breath-hold.

Conditions2

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