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Innate Immune Cell Phenotypes and Early Fibrotic Repair in Acute Myocardial Infarction

RECRUITINGSponsored by Shanghai 10th People's Hospital
Actively Recruiting
SponsorShanghai 10th People's Hospital
Started2026-01-01
Est. completion2026-12-31
Eligibility
Age18 Years – 80 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07764588

Summary

To determine the relationship of the phenotypes of neutrophils and monocytes with early fibrotic repair after acute myocardial infarction.

Eligibility

Age: 18 Years – 80 YearsHealthy volunteers accepted
Inclusion Criteria:

\---- Age \> 18 and ≤ 80 years old

\- Patients with acute STEMI within 12 hours of symptom onset who are planned to receive PPCI

Exclusion Criteria:

* Prior revascularization
* Known allergy to gadopentetate dimeglumine contrast agent
* Pregnancy or planned pregnancy within the next 6 months
* Life expectancy \< 1 year
* Metallic implants or claustrophobia that precluded MRI
* Severe COPD or inability to hold breath for MRI
* Severe hepatic or renal dysfunction (ALT \> 5×ULN or eGFR \< 15 mL/min/1.73 m²)

Conditions2

Heart DiseaseMyocardial Infarction

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