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Uterine Lavage to Detect Ovarian Cancer Risk

RECRUITINGN/ASponsored by University of Washington
Actively Recruiting
PhaseN/A
SponsorUniversity of Washington
Started2026-09-03
Est. completion2028-06-01
Eligibility
Age18 Years+
SexFEMALE
Healthy vol.Accepted
Locations1 site
View on ClinicalTrials.gov →

NCT07772869

Summary

This clinical trial develops a non-surgical approach using uterine lavage samples to screen for progression to ovarian cancer in high-risk patients carrying BRCA mutations. Women with inherited mutations in the BRCA1 and BRCA2 genes (BRCA carriers) have a much higher lifetime risk of developing ovarian cancer. Currently there are no effective ovarian cancer screening or early detection tests for BRCA carriers. Uterine lavage is a procedure that uses saline to rinse and collect cells from the fallopian tube. Molecular analysis of these samples may help proactively detect genetic alterations that are indicative of progression to ovarian cancer in women with BRCA mutations.

Eligibility

Age: 18 Years+Sex: FEMALEHealthy volunteers accepted
Inclusion Criteria:

* \> 18 years of age
* Have a pathogenic BRCA1 or BRCA2 germline variant
* Planned risk-reduction surgery
* Presence of uterus and at least one fallopian tube

Exclusion Criteria:

* Prior tubal ligation
* Prior history of known ovarian or endometrial cancer

Conditions5

BRCA Hereditary Ovarian CarcinomaCancerFallopian Tube High Grade Serous AdenocarcinomaOvarian High Grade Serous AdenocarcinomaPrimary Peritoneal High Grade Serous Adenocarcinoma

Locations1 site

Fred Hutch/University of Washington Cancer Consortium
Seattle, Washington, 98109
Intake Coordinators206-616-3913swisherlabrc@uw.edu

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