Sleep Apnea Biomarkers and Adherence to Continuous Positive Airway Pressure

Summary

Obstructive sleep apnea (OSA) is commonly assessed using the apnea-hypopnea index, although this measure does not fully reflect cardiovascular risk or the physiological impact of the disease. Emerging biomarkers, including sleep apnea-specific hypoxic burden, pulse wave amplitude drop index, and heart rate response, may provide additional information on cardiovascular vulnerability. This prospective multicenter observational study will investigate the association between these biomarkers, measured from the diagnostic sleep study, and adherence to continuous positive airway pressure (CPAP) therapy after three months. Symptoms, quality of life, clinical characteristics, and changes in biomarkers under continuous positive airway pressure will also be evaluated.

Eligibility

Inclusion Criteria:

* Newly diagnosed obstructive sleep apnea with an indication for continuous positive airway pressure therapy
* Age older than 18 years
* Written informed consent obtained

Exclusion Criteria:

* Continuous positive airway pressure treatment during the preceding 3 months
* Medical contraindication to continuous positive airway pressure therapy
* Concomitant condition likely to affect adherence to continuous positive airway pressure, including severe cognitive impairment or an unstable psychiatric disorder

Conditions4

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