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New Approaches for the Diagnosis of Lymphoma and Multicentric Castleman Disease

RECRUITINGN/ASponsored by Indiana University
Actively Recruiting
PhaseN/A
SponsorIndiana University
Started2025-03-17
Est. completion2028-12
Eligibility
Age1 Year+
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07793006

Summary

Persons living with HIV (PLWH) in sub-Saharan Africa (SSA), lymphadenopathy often portends one of a number of life-threatening diseases including tuberculosis, lymphoma, and multicentric Castleman disease (MCD). Overcoming these delays and missed diagnoses requires new approaches to identify lymphoma and MCD.

Eligibility

Age: 1 Year+Healthy volunteers accepted
Inclusion Criteria:

* Age ≥1 year old and body weight of ≥ 10 kg.
* HIV-infected.
* Unexplained lymphadenopathy with at least one lymph node ≥2 cm that is amenable to biopsy.
* Willing and able to give informed consent if the subject is 18 years of age or older, adolescent assent and legal guardian consent for subjects 15-17 years of age, pediatric assent and legal guardian consent for subjects 7-14 years of age, or legal guardian consent for pediatric subjects less than 7 years of age.

Exclusion Criteria:

* Cannot or is not willing to follow study procedures.
* Subjects with a previous history of cancer in the last five years with the exception of subjects with Kaposi sarcoma (i.e. history of Kaposi sarcoma is allowed in the study).

Conditions7

CancerHIVHodgkin LymphomaKaposi Sarcoma Herpesvirus -Associated Multicentric Castleman DiseaseLymphadenopathyNon-hodgkin LymphomaTiny Isothermal Nucleic Acid Amplification System

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