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Effect of Intravenous Magnesium on Postoperative Systemic Inflammatory Response in Patients Undergoing Colorectal Cancer Surgery

RECRUITINGN/ASponsored by Ain Shams University
Actively Recruiting
PhaseN/A
SponsorAin Shams University
Started2026-03-01
Est. completion2027-03-01
Eligibility
Age35 Years – 75 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07803601

Summary

The aim of this study is to detect the effect of intraoperative intravenous magnesium sulfate on postoperative systemic inflammatory response by serum inflammatory parameters as CRP, WBCS and neutrophil count.

Eligibility

Age: 35 Years – 75 YearsHealthy volunteers accepted
Inclusion Criteria:

* ASA I and ASA II.
* Age (35yrs - 75yrs).
* Patients undergoing open colorectal cancer surgery.
* Sex: Both sexes.

Exclusion Criteria:

* Renal impairment (Glomerular Filtration Rate \< 60 ml\\min).
* Severe cardiac dysfunction (Ejection fraction ≤ 30% or clinical signs and symptoms of reduced left ventricular ejection fraction), preoperative bradycardia (HR \< 50 bpm) and atrioventricular block (first, second and third degree).
* Allergy to study drug (MgSO4).
* Patient refusal to precipitate in this study.
* Autoimmune disorders (eg: rheumatoid arthritis, multiple sclerosis and lupus), congenital and acquired immunodeficiency.
* Previous / current immunomodulatory therapy.
* Emergency condition (eg: obstruction or perforation in colorectal cancer).
* Postoperative complications altering inflammatory response (eg: infection, anastomotic leak).
* Duration of operation \> 5 hours.
* Cognitive impairment (eg: Dementia) and other psychiatric disorders by history.
* Body mass index less than 18 or greater than 30 kg/m².

Conditions3

CancerPost Operative Inflammatory Marker LevelsPost Operative Pain

Interventions1

Magnesium sulfate (MgSO4)

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