Trastuzumab Deruxtecan Clinical Trials

54 actively recruiting trials across 20 locations

Also known as: A1811, DS-8201, DS-8201a, DS-8201a (trastuzumab derextecan), DS-8201a, Enhertu, DS-8201a, T-DXd, DS-8201a; T-DXd, ENHERTU®, Enhertu, Enhertu®, Fam-trastuzumab Deruxtecan-nxki, T-DXd, T-DXd, DS-8201, T-DXd, Enhertu, T-DXd; Enhertu®, WHO 10516, am-trastuzumab deruxtecan-nxki, fam-trastuzumab deruxtecan-nxki

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Other20 trials

A Phase II Study of HLX22 in Combination With Trastuzumab Deruxtecan in HER2-low, Hormone Receptor Positive Locally Advanced or Metastatic Breast Cancer Patients

Phase 2

A Randomized Secondary Adjuvant Treatment Intervention Study Comparing Trastuzumab-Deruxtecan to SOC Therapy in eBC Patients With Molecular Relapse

Phase 3

A Study of T-DXd as Monotherapy or in Combination With Anti-cancer Agents in Patients With Selected HER2-expressing Tumors

Phase 2

A Study of Trastuzumab DeRuxtecan for Patients With Advanced HER2-pOsitive GaStric or GastroesoPhageal Junction AdEnocarcinoma Who Have Received a PrIor Trastuzumab-based Regimen Accompanied by a Disease RegistrY of Patients Treated With Conventional Therapies (PROSPERITY)

A Study to Assess the Effectiveness of Trastuzumab Deruxtecan in Chinese Breast Cancer Patients (REFRESH)

Anlotinib With Trastuzumab Deruxtecan for Previously Treated HER2-Low Advanced Breast Cancer

Phase 1

Basket Study for Oligo-metastatic Breast Cancer

Phase 2

DESTINY Breast Respond HER2-low Europe

Developing ctDNA Guided Adjuvant Therapy for Gastrooesophageal Cancer

Phase 2

Efficacy of Trastuzumab Deruxtecan in Metastatic Breast Cancer with Different HER2 Expression Patterns

HCQ+ADC vs ADC in the Treatment of Advanced Breast Cancer

Phase 1/2

Neoadjuvant Trastuzumab Deruxtecan (SHR-A1811) + Pertuzumab in HER2+ Breast Cancer

Phase 2

Organoid-based Functional Precision Therapy for Advanced Breast Cancer

Phase 2

Perioperative Therapies in Locally Advanced Unresectable Gastric Cancer

Phase 2

Phase 4 Study to Assess the Safety of Trastuzumab Deruxtecan, in Indian Patients

Phase 4

Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)

Phase 2

Real-world Study of Trastuzumab Deruxtecan in Patients With Unresectable or Metastatic HER2-low Breast Cancer

Trastuzumab Deruxtecan Versus Standard Neoadjuvant Treatment for HER2-positive Breast Cancer

Phase 2

Trastuzumab Deruxtecan in Advanced Breast Cancer

Trastuzumab Deruxtecan(T-DXd) and Afatinib Combination in HER2-low Advanced Gastric Cancer

Phase 1/2

Boston, Massachusetts5 trials

PHESGO Maintenance After T-DXd Short Induction for HER2+ Unresectable Locally Recurrent or Metastatic Breast Cancer

Dana-Farber Cancer Institute

Phase 2

Scalp Cooling in MBC

Brigham and Women's Hospital

Phase 2

TRUDI: TDXD+Durva in HER2+/Low IBC

Brigham and Women's Hospital

Phase 2

Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

Dana-Farber - Harvard Cancer Center LAO

Phase 1

The SAPPHO Study: Sequential Therapy With Curative Intent in de Novo HER2+ Metastatic Breast Cancer

Dana-Farber Cancer Institute

Phase 2

Birmingham, Alabama3 trials

DESTINY-PANTUMOUR04

Research Site

TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd

University of Alabama

Phase 2

Testing the Use of Ado-Trastuzumab Emtansine Compared to the Usual Treatment (Chemotherapy With Docetaxel Plus Trastuzumab) or Trastuzumab Deruxtecan for Recurrent, Metastatic, or Unresectable HER2-Expressing Salivary Gland Cancers

University of Alabama at Birmingham Cancer Center

Phase 2

Duarte, California3 trials

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer

City of Hope

Phase 1/2

An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis

City of Hope Medical Center

Phase 4

Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

City of Hope Comprehensive Cancer Center

Phase 2

New Haven, Connecticut3 trials

SNV1521 in Participants with Advanced Solid Tumors

Yale University

Phase 1

Study of TDXd, Chemotherapy, Pembrolizumab, and Trastuzumab in First-Line Metastatic HER2-Positive Gastric or Gastroesophageal Junction Cancer

Yale Cancer Center

Phase 3

Trial of Trastuzumab Deruxtecan in Previously Treated HER2

Yale University

Phase 2

Anchorage, Alaska2 trials

A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

Research Site

Phase 3

Study of Trastuzumab Deruxtecan, Pembrolizumab, and Platinum-based Chemotherapy in First-line HER2 Overexpressing Non-small Cell Lung Cancer

Alaska Oncology & Hematology, LLC

Phase 3

Phoenix, Arizona2 trials

Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

Mayo Clinic-Arizona

Phase 1/2

Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer

Mayo Clinic Hospital in Arizona

Phase 1

Miami Beach, Florida2 trials

Study of Trastuzumab Deruxtecan Versus Standard of Care Chemotherapy for HER2-Expressing (IHC 3+/2+) Endometrial Cancer

Mount Sinai Medical Center

Phase 3

Trastuzumab Deruxtecan (T-DXd) in Patients Who Have Hormone Receptor-negative and Hormone Receptor-positive HER2-low or HER2 IHC 0 Metastatic Breast Cancer

Mount Sinai Medical Center

Phase 3

Tampa, Florida2 trials

Sequential Therapies Modeled on Evolutionary Dynamics for Breast Cancer

Moffitt Cancer Center

Phase 2

Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation

Moffitt Cancer Center-International Plaza

Phase 1/2

Daphne, Alabama1 trial

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

Southern Cancer Center (SCC) ( Site 8000)

Phase 3

Scottsdale, Arizona1 trial

Phase 3 Study of T-DXd and Rilvegostomig Versus SoC in Advanced HER2-expressing Biliary Tract Cancer

Research Site

Phase 3

Tucson, Arizona1 trial

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Research Site

Phase 3

Burbank, California1 trial

A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors

Research Site

Phase 2

Fullerton, California1 trial

Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer

St. Joseph Heritage Healthcare

Phase 2

Irvine, California1 trial

Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Phase 1

La Jolla, California1 trial

Study of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy for First-line Maintenance in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01)

Scripps Clinic

Phase 3

Newport Beach, California1 trial

A Study of Subcutaneous Trastuzumab Deruxtecan in Participants With Metastatic Solid Tumors

Research Site

Phase 1

Santa Monica, California1 trial

Ph1b/2 Study of the Safety and Efficacy of T-DXd Combinations in Advanced HER2-expressing Gastric Cancer (DESTINY-Gastric03)

Research Site

Phase 2

Ann Arbor, Michigan1 trial

A Study of Trastuzumab Deruxtecan in People With Non-Small Cell Lung Cancer

University of Michigan (Data Collection Only)

Phase 2

New York, New York1 trial

Trastuzumab Deruxtecan (T-DXd) for People With Brain Cancer

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

Phase 2

Houston, Texas1 trial

EIS-12656 as Single Agent and in Combination in Patients With Specified Solid Tumors

MD Anderson Cancer Center

Phase 1/2

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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